{"id":6816,"date":"2023-09-25T08:26:01","date_gmt":"2023-09-25T08:26:01","guid":{"rendered":"https:\/\/www.needinstitute.org\/?p=6816"},"modified":"2023-09-25T08:26:01","modified_gmt":"2023-09-25T08:26:01","slug":"neurobiologist-researcher-on-amyotrophic-lateral-sclerosis-als","status":"publish","type":"post","link":"https:\/\/www.needinstitute.org\/en\/neurobiologist-researcher-on-amyotrophic-lateral-sclerosis-als\/","title":{"rendered":"Neurobiologist Researcher on Amyotrophic Lateral Sclerosis (ALS)"},"content":{"rendered":"<p>Rachele Marino received her Master&#8217;s degree in Genetics and Molecular Biology from &#8220;La Sapienza&#8221; University of Rome and completed her internship at the Department of Molecular Medicine, where she studied the role of \u201cpaused promoters\u201d in acute myeloid leukemia (AML), demonstrating that aberrant DNA hypermethylation is associated with a significant reduction of H3K4 chromatin marker in an AML cellular model.<br \/>\nShe then completed a PhD in Human Biology and Medical Genetics from &#8220;La Sapienza,&#8221; where she studied the role and function of Argonauta2 during senescence and identified the nuclear key interactors of this protein.<br \/>\nDr. Marino continued her career in neuroscience at the Ebri-Rita Levi Montalcini Foundation in Rome, where she investigated the role of SUMOylation in neurodegenerative diseases that include Amyotrophic Lateral Sclerosis (ALS), Alzheimer&#8217;s, and Parkinson&#8217;s. She explored the regulatory mechanism of TAU aggregation and its post-transcriptional control, specifically SUMOylation, in primary neurons and neuroblastoma cell lines.<br \/>\nSince August 2023, Rachele Marino, as a researcher at the <em>Need Institute<\/em>, has received a scholarship that allows her to continue her research focusing on the mechanism of the re-localization and aggregation of the TDP-43 protein at the cytoplasmic level, which is a hallmark of ALS pathology.<br \/>\nParticularly, she will evaluate how TDP43 SUMOylation impacts the citotoxicity in primary neurons and fibroblasts derived from ALS patients.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rachele Marino received her Master&#8217;s degree in Genetics and Molecular Biology from &#8220;La Sapienza&#8221; University of Rome and completed her internship at the Department of Molecular Medicine, where she studied the role of \u201cpaused promoters\u201d in acute myeloid leukemia (AML), demonstrating that aberrant DNA hypermethylation is associated with a significant reduction of H3K4 chromatin marker<\/p>\n","protected":false},"author":1,"featured_media":6812,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[44],"tags":[],"class_list":["post-6816","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-novita-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Neurobiologist Researcher on Amyotrophic Lateral Sclerosis (ALS) - Need Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.needinstitute.org\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Neurobiologist Researcher on Amyotrophic Lateral Sclerosis (ALS) - Need Institute\" \/>\n<meta property=\"og:description\" content=\"Rachele Marino received her Master&#8217;s degree in Genetics and Molecular Biology from &#8220;La Sapienza&#8221; University of Rome and completed her internship at the Department of Molecular Medicine, where she studied the role of \u201cpaused promoters\u201d in acute myeloid leukemia (AML), demonstrating that aberrant DNA hypermethylation is associated with a significant reduction of H3K4 chromatin marker\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.needinstitute.org\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Need Institute\" \/>\n<meta property=\"article:published_time\" content=\"2023-09-25T08:26:01+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.needinstitute.org\/wp-content\/uploads\/2023\/09\/master-afasiologia-2-1-560x315-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"560\" \/>\n\t<meta property=\"og:image:height\" content=\"315\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Need Institute\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Need Institute\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.needinstitute.org\\\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.needinstitute.org\\\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\\\/\"},\"author\":{\"name\":\"Need Institute\",\"@id\":\"https:\\\/\\\/www.needinstitute.org\\\/#\\\/schema\\\/person\\\/f1f401a3fbe10efa590fd14cd9c003dc\"},\"headline\":\"Neurobiologist Researcher on Amyotrophic Lateral Sclerosis (ALS)\",\"datePublished\":\"2023-09-25T08:26:01+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.needinstitute.org\\\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\\\/\"},\"wordCount\":225,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/www.needinstitute.org\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.needinstitute.org\\\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.needinstitute.org\\\/wp-content\\\/uploads\\\/2023\\\/09\\\/master-afasiologia-2-1-560x315-1.jpg\",\"articleSection\":[\"novit\u00e0\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.needinstitute.org\\\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\\\/\",\"url\":\"https:\\\/\\\/www.needinstitute.org\\\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\\\/\",\"name\":\"Neurobiologist Researcher on Amyotrophic Lateral Sclerosis (ALS) - Need Institute\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.needinstitute.org\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.needinstitute.org\\\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.needinstitute.org\\\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.needinstitute.org\\\/wp-content\\\/uploads\\\/2023\\\/09\\\/master-afasiologia-2-1-560x315-1.jpg\",\"datePublished\":\"2023-09-25T08:26:01+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.needinstitute.org\\\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.needinstitute.org\\\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.needinstitute.org\\\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.needinstitute.org\\\/wp-content\\\/uploads\\\/2023\\\/09\\\/master-afasiologia-2-1-560x315-1.jpg\",\"contentUrl\":\"https:\\\/\\\/www.needinstitute.org\\\/wp-content\\\/uploads\\\/2023\\\/09\\\/master-afasiologia-2-1-560x315-1.jpg\",\"width\":560,\"height\":315},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.needinstitute.org\\\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.needinstitute.org\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Neurobiologist Researcher on Amyotrophic Lateral Sclerosis (ALS)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.needinstitute.org\\\/#website\",\"url\":\"https:\\\/\\\/www.needinstitute.org\\\/\",\"name\":\"Need Institute\",\"description\":\"Neurological Expertise and Dedication\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.needinstitute.org\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.needinstitute.org\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.needinstitute.org\\\/#organization\",\"name\":\"Need Institute\",\"url\":\"https:\\\/\\\/www.needinstitute.org\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.needinstitute.org\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.needinstitute.org\\\/wp-content\\\/uploads\\\/2017\\\/10\\\/Logo_need_institute_high.png\",\"contentUrl\":\"https:\\\/\\\/www.needinstitute.org\\\/wp-content\\\/uploads\\\/2017\\\/10\\\/Logo_need_institute_high.png\",\"width\":653,\"height\":240,\"caption\":\"Need Institute\"},\"image\":{\"@id\":\"https:\\\/\\\/www.needinstitute.org\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.needinstitute.org\\\/#\\\/schema\\\/person\\\/f1f401a3fbe10efa590fd14cd9c003dc\",\"name\":\"Need Institute\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/5fb1e433d2bd18ec85e0df18de03f2808900466ec94af2f6e535b151e395e843?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/5fb1e433d2bd18ec85e0df18de03f2808900466ec94af2f6e535b151e395e843?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/5fb1e433d2bd18ec85e0df18de03f2808900466ec94af2f6e535b151e395e843?s=96&d=mm&r=g\",\"caption\":\"Need Institute\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Neurobiologist Researcher on Amyotrophic Lateral Sclerosis (ALS) - Need Institute","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.needinstitute.org\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\/","og_locale":"en_US","og_type":"article","og_title":"Neurobiologist Researcher on Amyotrophic Lateral Sclerosis (ALS) - Need Institute","og_description":"Rachele Marino received her Master&#8217;s degree in Genetics and Molecular Biology from &#8220;La Sapienza&#8221; University of Rome and completed her internship at the Department of Molecular Medicine, where she studied the role of \u201cpaused promoters\u201d in acute myeloid leukemia (AML), demonstrating that aberrant DNA hypermethylation is associated with a significant reduction of H3K4 chromatin marker","og_url":"https:\/\/www.needinstitute.org\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\/","og_site_name":"Need Institute","article_published_time":"2023-09-25T08:26:01+00:00","og_image":[{"width":560,"height":315,"url":"https:\/\/www.needinstitute.org\/wp-content\/uploads\/2023\/09\/master-afasiologia-2-1-560x315-1.jpg","type":"image\/jpeg"}],"author":"Need Institute","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Need Institute","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.needinstitute.org\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\/#article","isPartOf":{"@id":"https:\/\/www.needinstitute.org\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\/"},"author":{"name":"Need Institute","@id":"https:\/\/www.needinstitute.org\/#\/schema\/person\/f1f401a3fbe10efa590fd14cd9c003dc"},"headline":"Neurobiologist Researcher on Amyotrophic Lateral Sclerosis (ALS)","datePublished":"2023-09-25T08:26:01+00:00","mainEntityOfPage":{"@id":"https:\/\/www.needinstitute.org\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\/"},"wordCount":225,"commentCount":0,"publisher":{"@id":"https:\/\/www.needinstitute.org\/#organization"},"image":{"@id":"https:\/\/www.needinstitute.org\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\/#primaryimage"},"thumbnailUrl":"https:\/\/www.needinstitute.org\/wp-content\/uploads\/2023\/09\/master-afasiologia-2-1-560x315-1.jpg","articleSection":["novit\u00e0"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.needinstitute.org\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\/","url":"https:\/\/www.needinstitute.org\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\/","name":"Neurobiologist Researcher on Amyotrophic Lateral Sclerosis (ALS) - Need Institute","isPartOf":{"@id":"https:\/\/www.needinstitute.org\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.needinstitute.org\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\/#primaryimage"},"image":{"@id":"https:\/\/www.needinstitute.org\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\/#primaryimage"},"thumbnailUrl":"https:\/\/www.needinstitute.org\/wp-content\/uploads\/2023\/09\/master-afasiologia-2-1-560x315-1.jpg","datePublished":"2023-09-25T08:26:01+00:00","breadcrumb":{"@id":"https:\/\/www.needinstitute.org\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.needinstitute.org\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.needinstitute.org\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\/#primaryimage","url":"https:\/\/www.needinstitute.org\/wp-content\/uploads\/2023\/09\/master-afasiologia-2-1-560x315-1.jpg","contentUrl":"https:\/\/www.needinstitute.org\/wp-content\/uploads\/2023\/09\/master-afasiologia-2-1-560x315-1.jpg","width":560,"height":315},{"@type":"BreadcrumbList","@id":"https:\/\/www.needinstitute.org\/ricercatrice-neurobiologa-sulla-sclerosi-laterale-amiotrofica-2\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.needinstitute.org\/en\/"},{"@type":"ListItem","position":2,"name":"Neurobiologist Researcher on Amyotrophic Lateral Sclerosis (ALS)"}]},{"@type":"WebSite","@id":"https:\/\/www.needinstitute.org\/#website","url":"https:\/\/www.needinstitute.org\/","name":"Need Institute","description":"Neurological Expertise and Dedication","publisher":{"@id":"https:\/\/www.needinstitute.org\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.needinstitute.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.needinstitute.org\/#organization","name":"Need Institute","url":"https:\/\/www.needinstitute.org\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.needinstitute.org\/#\/schema\/logo\/image\/","url":"https:\/\/www.needinstitute.org\/wp-content\/uploads\/2017\/10\/Logo_need_institute_high.png","contentUrl":"https:\/\/www.needinstitute.org\/wp-content\/uploads\/2017\/10\/Logo_need_institute_high.png","width":653,"height":240,"caption":"Need Institute"},"image":{"@id":"https:\/\/www.needinstitute.org\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/www.needinstitute.org\/#\/schema\/person\/f1f401a3fbe10efa590fd14cd9c003dc","name":"Need Institute","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/5fb1e433d2bd18ec85e0df18de03f2808900466ec94af2f6e535b151e395e843?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/5fb1e433d2bd18ec85e0df18de03f2808900466ec94af2f6e535b151e395e843?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/5fb1e433d2bd18ec85e0df18de03f2808900466ec94af2f6e535b151e395e843?s=96&d=mm&r=g","caption":"Need Institute"}}]}},"_links":{"self":[{"href":"https:\/\/www.needinstitute.org\/en\/wp-json\/wp\/v2\/posts\/6816","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.needinstitute.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.needinstitute.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.needinstitute.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.needinstitute.org\/en\/wp-json\/wp\/v2\/comments?post=6816"}],"version-history":[{"count":1,"href":"https:\/\/www.needinstitute.org\/en\/wp-json\/wp\/v2\/posts\/6816\/revisions"}],"predecessor-version":[{"id":6817,"href":"https:\/\/www.needinstitute.org\/en\/wp-json\/wp\/v2\/posts\/6816\/revisions\/6817"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.needinstitute.org\/en\/wp-json\/wp\/v2\/media\/6812"}],"wp:attachment":[{"href":"https:\/\/www.needinstitute.org\/en\/wp-json\/wp\/v2\/media?parent=6816"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.needinstitute.org\/en\/wp-json\/wp\/v2\/categories?post=6816"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.needinstitute.org\/en\/wp-json\/wp\/v2\/tags?post=6816"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}